Intergovernmental relations refer to the set of formal and informal channels through which governments from different levels cooperate and jointly act upon policy matters. These policy matters usually involve complex problems that span across governmental boundaries, thus creating the need for a cooperative approach to tackle them. In the context of digitalization, such relations gain new contours in the face of increasing demands for seamless, integrated, and streamlined digital services. On the one hand, digitalization creates unparalleled opportunities for governments to work together on projects of common interest, promote mutual learning, and scale-up solutions. On the other, it also leaves room for conflicts around the strategies to adopt and accountability weaknesses. In this presentation, we will unpack some of the most pressing issues in intergovernmental relations in the digital age. Based on case studies, we will discuss the most common challenges to intergovernmental relations in the context of digitalization. We will also analyze best practices that illustrate how governments can overcome difficulties and draw on the potential of digitalization to leverage intergovernmental relations.